- Title
- Enhanced degradation mechanism of anticancer drug irinotecan through low-frequency ultrasound assisted reactive electrochemical membrane
- Creator
- Meng, Xinxin; Liu, Zhun; Qian, Xubin; Tang, Shaoyu; Fang, Cheng; Niu, Junfeng; Xu, Lei
- Relation
- ARC.SR180200015 http://purl.org/au-research/grants/arc/SR180200015
- Relation
- Journal of Cleaner Production Vol. 383, Issue 10 January 2023, no. 135419
- Publisher Link
- http://dx.doi.org/10.1016/j.jclepro.2022.135419
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2023
- Description
- The effect of low-frequency ultrasound (US, 20 kHz, 104 W) on the degradation of anticancer drug irinotecan (IRI) using reactive electrochemical membrane (REM) was investigated. Results demonstrated that higher k value (0.103 min−1) and mineralization efficiency (94.6%) as well as lower energy consumption (0.906 Wh L−1) were observed in US-REM system. The effects of influence factors including US power, volume flow rate, current density and initial IRI concentration on the degradation of IRI were studied in US-REM system. The relative contributions of •OH, SO4•− and O2•− (indirect oxidation) to IRI degradation using REM were all increased with the assistance of US. The production rate of •OH using US-REM increased by 19.7% compared with that using REM. Seven intermediates of IRI degradation using both REM and US-REM were identified, and the main degradation pathways of IRI were hydroxylation, oxidation and ring cleavage. The enhanced degradation and mineralization of IRI in US-REM system could mainly be attributed to higher •OH production and higher contribution of free radicals.
- Subject
- irinotecan; electrochemical oxidation; low-frequency ultrasound; reactive electrochemical membrane; mechanism; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1480992
- Identifier
- uon:50611
- Identifier
- ISSN:0959-6526
- Language
- eng
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